Cytopathic effect – Communicable Diseases Research

Identification and characterization of the anti-SARS-CoV-2 activity of cationic amphiphilic steroidal compounds

양이온성 양친매성 스테로이드 화합물의 항 SARS-CoV-2 활성의 확인 및 특성화

Article

Published on 2022-12-012022-09-11
Journal: Virulence
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제,

Multi-target mechanisms against coronaviruses of constituents from Chinese Dagang Tea revealed by experimental and docking studies

실험 및 도킹 연구를 통해 밝혀진 중국 Dagang Tea 성분의 코로나바이러스에 대한 다중 표적 메커니즘

Article

Published on 2022-10-282022-09-11
Journal: Journal of ethnopharmacology
[Category] COVID19(2023년), SARS, 치료제,

[키워드] Analysis analysis antibody antiviral activity Antiviral effect betulinic acid Chemical profile China Chinese Cold colds Compound coronavirus coronavirus Coronaviruses CPE Cytopathic effect demonstrated docking docking analysis docking study Efficacy enzyme Enzyme inhibition eriodictyol Eurya evaluated exhibited experiment Fever fevers flavonoids Guangdong HCoV-OC43 herbal tea immunofluorescence in vitro infected cells Influenza inhibitory effect Inhibitory effects material mechanism Microscopic monomer naringenin OC43 optical performed PLPro Potential treatment potential treatments Prevent quercetin reduction SARS-CoV-2 tea Traditional Chinese medicine transmission electron microscopy treat Treatment viral infections Virtual screening virus particle virus particles
[DOI] 10.1016/j.jep.2022.115528 PMC 바로가기 [Article Type] Article

Safety, immunogenicity, and immune persistence of two inactivated COVID-19 vaccines replacement vaccination in China: An observational cohort study

Article

Published on 2022-09-162022-11-15
Journal: Vaccine
[Category] SARS, 진단,

Molecular Analyses of Clinical Isolates and Recombinant SARS-CoV-2 Carrying B.1 and B.1.617.2 Spike Mutations Suggest a Potential Role of Non-Spike Mutations in Infection Kinetics

Article

Published on 2022-09-122022-11-15
Journal: Viruses
[Category] SARS, 변종, 진단,

[키워드] acute respiratory syndrome addition analysis B.1 B.1.617.2 BAC BAC mutagenesis backbone Bacterial bronchial epithelial cells Carrying chromosome clinical comparable coronavirus Cytopathic effect disease Efficiency en passant mutagenesis epithelial cell line evaluate generate glycoprotein human lung Infection infectious virus inhibitors isolate isolates Kinetics less Microscopy monoclonal antibody Mutagenesis Mutation neutralization nonstructural proteins nucleocapsid Numerous Post-vaccine Potential progression raise recombinant RNA role SARS-CoV-2 sera severity spike spike mutation spike mutations Spike protein spike protein. Substitution suggested susceptible Syncytia Transmissibility Treatment variant viral fitness viral spike virus Virus life cycle VoC
[DOI] 10.3390/v14092017 PMC 바로가기

Factors associated with neutralizing antibody levels induced by two inactivated COVID-19 vaccines for 12 months after primary series vaccination

Article

Published on 2022-09-092022-11-15
Journal: Frontiers in Immunology
[Category] SARS, 진단,

[키워드] age analyzed anti-SARS-CoV-2 antibody BBIBP-CorV blood sample booster dose booster doses change Chi-square China convalescent convalescent sera CoronaVac COVID-19 COVID-19 vaccine cross-sectional Cytopathic effect dose enrolled evaluated Factor Factors FIVE geometric mean concentration geometric mean titer GMC GMT immune immune persistence immunogenicity Immunoglobulin inactivated individual influencing factors. linear models Logistic regression NAb neutralizing antibody NIBSC nine number ranged real-world data recipient recipients sample sizes SARS-CoV-2 SARS-CoV-2 strain seropositive Seropositivity Sex Standard subject understanding vaccination Vaccine Vaccines Vero Cell were measured WHO Zhejiang
[DOI] 10.3389/fimmu.2022.967051 PMC 바로가기

Nicotine in Combination with SARS-CoV-2 Affects Cells Viability, Inflammatory Response and Ultrastructural Integrity

SARS-CoV-2와 결합된 니코틴은 세포 생존, 염증 반응 및 미세구조 완전성에 영향을 미칩니다

Article

Published on 2022-08-222022-09-12
Journal: International Journal of Molecular Sciences
[Category] SARS, 진단,

[키워드] A549 A549 cell analyzed caused Cell cellular damage characterized chromatin Combination COVID-19 cytokine production Cytokines Cytopathic effect cytopathic effects cytoplasmic cytosol cytotoxicity decrease dose Endoplasmic reticulum expression level extracellular space feature granules human lung human lung adenocarcinoma A549 cells IL10 IL6 IL8 infected with SARS-CoV-2 Inflammatory cytokine Inflammatory cytokines integrity LPS mechanism of action membrane rupture Modification modifications modulate necroptosis Nicotine poly(I:C) positive proinflammatory proinflammatory cytokines protective role pyroptosis pyroptosis. response SARS-CoV-2 TNFα Vero E6 cell were used
[DOI] 10.3390/ijms23169488 PMC 바로가기 [Article Type] Article

Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease

SARS-CoV-2 파파인 유사 프로테아제의 알로스테릭 부위에서 복합체 내 천연 페놀 화합물의 항바이러스 활성

Article

Published on 2022-08-112022-09-11
Journal: Communications Biology
[Category] SARS, 변종, 신약개발, 치료제,

Beta interferons from the extant camelids: Unique among eutherian mammals

현존하는 낙타과의 베타 인터페론: eutherian 포유류 중 유일

Article

Published on 2022-08-012022-09-11
Journal: Developmental and comparative immunology
[Category] 유전자 메커니즘, 조류인플루엔자, 치료제,

[키워드] Antiviral antiviral response Beta camelid Cell cells coronavirus COVID-19 pandemic cysteine cysteines Cytopathic effect cytopathic effects Defense Dromedary Dromedary camel Endemic event expressed expression Host immune response IFN-β immune mechanism induction Infection interferon interferons invading pathogen invading pathogens kidney mammal mammals MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus molecular offer Outbreaks pandemic pathogen Pathogens poly(I:C) poxvirus Protein recombinant IFN-β respiratory syndrome coronavirus RNA virus Treatment unique virus zoonosis zoonosis. zoonotic zoonotic infections
[DOI] 10.1016/j.dci.2022.104443 PMC 바로가기 [Article Type] Article

The Prospective Effect of Allopurinol on the Oxidative Stress Index and Endothelial Dysfunction in Covid-19

코로나19의 산화 스트레스 지수와 내피 기능 장애에 대한 알로퓨리놀의 전향적 효과

Article

Published on 2022-08-012022-09-11
Journal: Inflammation
[Category] COVID19(2023년), SARS, 바이오마커,

[키워드] addition Admission allopurinol antioxidant Biomarker Biomarkers clinical outcomes cohort study correlated COVID-19 patients COVID-19 severity CRP CT scan Cytokines Cytopathic effect D-dimer dimer discharge Effect endothelial Endothelial dysfunction Endothelin Endothelin-1 enzyme ET-1 evaluated ferritin Gout Hospitalization index Inflammatory Inflammatory biomarker inflammatory biomarkers inflammatory disorder inflammatory disorders inflammatory disorders. inflammatory reaction LDH lymphocyte metabolism neutrophil NLR oxidative oxidative stress oxidative stress. Patient pro-inflammatory cytokine pro-inflammatory cytokines procalcitonin procalcitonin) Propagation Prospective protective effect purine recruited reduced reported SARS-CoV-2 Serum level severe COVID-19 severe COVID-19 patients severity significantly single-center Standard therapy standard treatment standard treatment alone three groups Treatment triggered uric acid Viral viral infections xanthine
[DOI] 10.1007/s10753-022-01648-7 PMC 바로가기 [Article Type] Article

Developing New Treatments for COVID-19 through Dual-Action Antiviral/Anti-Inflammatory Small Molecules and Physiologically Based Pharmacokinetic Modeling

이중 작용 항바이러스/항염 소분자 및 생리학적 기반 약동학 모델링을 통한 COVID-19에 대한 새로운 치료법 개발

Review

Published on 2022-07-202022-09-11
Journal: International Journal of Molecular Sciences
[Category] COVID19(2023년), SARS, 진단, 치료제,

[키워드] (dexamethasone Anti-inflammatory Anti-SARS-CoV-2 Activity Antiviral antiviral agent Antiviral agents approach Baricitinib biochemical pathway Biochemical pathways characterization COVID-19 COVID-19 pandemic Critical Cytopathic effect develop Developing Dexamethasone drug target dual dual action early treatment effective Efficacy and safety health system health systems High-risk patients identify in silico in vitro in vivo model Infection inflammatory cascade inhibitor inhibitors mechanism Mild mild to moderate Mild to moderate COVID-19 modeling Moderate COVID-19 molecular docking molecular docking. molecule molnupiravir monoclonal antibodies multidisciplinary approach New Nirmatrelvir pandemic pathogen PBPK modeling pharmacological protocol Ritonavir therapeutic agent therapeutic agents threat Treatment treatment of COVID-19 Viral virus virus viruses
[DOI] 10.3390/ijms23148006 PMC 바로가기 [Article Type] Review